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1

Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease

Halder, Maurice, Petsophonsakul, Ploingarm, Akbulut, Asim, Pavlic, Angelina, Bohan, Frode, Anderson, Eric, Maresz, Katarzyna, Kramann, Rafael, Schurgers, Leon

Journal:

International Journal of Molecular Sciences

Year:

2019

Language:

english

File:

PDF, 998 KB

english, 2019

2

Determination of Phylloquinone and Menaquinones in Food

Schurgers, Leon J., Vermeer, Cees

Journal:

Pathophysiology of Haemostasis and Thrombosis

Year:

2000

Language:

english

File:

PDF, 184 KB

english, 2000

3

Dietary Intake of Menaquinone Is Associated with a Reduced Risk of Coronary Heart Disease: The Rotterdam Study

Geleijnse, Johanna M., Vermeer, Cees, Grobbee, Diederick E., Schurgers, Leon J., Knapen, Marjo H. J., van der Meer, Irene M., Hofman, Albert, Witteman, Jacqueline C. M.

Journal:

Journal of Nutrition

Year:

2004

Language:

english

File:

PDF, 86 KB

english, 2004

4

Vitamin K2 Needs an RDI Separate from Vitamin K1

Akbulut, Asim Cengiz, Pavlic, Angelina, Petsophonsakul, Ploingarm, Halder, Maurice, Maresz, Katarzyna, Kramann, Rafael, Schurgers, Leon

Journal:

Year:

2020

File:

PDF, 781 KB

2020

5

Atypical presentation of pseudoxanthoma elasticum with abdominal cutis laxa: Evidence for a spectrum of ectopic calcification disorders?

Olivier M. Vanakker, Bart P. Leroy, Leon J. Schurgers, Cees Vermeer, Paul J. Coucke, Anne De Paepe

Journal:

American Journal of Medical Genetics Part A

Year:

2011

Language:

english

File:

PDF, 181 KB

english, 2011

6

Glia-induced neuronal differentiation by transcriptional regulation

Christian Göritz, Renaud Thiebaut, Luc-Henri Tessier, Katja Nieweg, Christoph Moehle, Isabelle Buard, Jean-Luc Dupont, Leon J. Schurgers, Gerd Schmitz, Frank W. Pfrieger

Journal:

Year:

2007

Language:

english

File:

PDF, 290 KB

english, 2007

7

Vitamin K supplementation increases vitamin K tissue levels but fails to counteract ectopic calcification in a mouse model for pseudoxanthoma elasticum

Theo G. M. F. Gorgels, Jan H. Waarsing, Marjolein Herfs, Daniëlle Versteeg, Frank Schoensiegel, Toshiro Sato, Reinier O. Schlingemann, Boris Ivandic, Cees Vermeer, Leon J. Schurgers, Arthur A. B. Berg

Journal:

Journal of Molecular Medicine

Year:

2011

Language:

english

File:

PDF, 536 KB

english, 2011

8

Differential lipoprotein transport pathways of K-vitamins in healthy subjects

Leon J. Schurgers, Cees Vermeer

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2002

Language:

english

File:

PDF, 252 KB

english, 2002

9

A COMPREHENSIVE REVIEW OF VITAMIN K AND VITAMIN K ANTAGONISTS

Vermeer, Cees, Schurgers, Leon J.

Journal:

Hematology/Oncology Clinics of North America

Year:

2000

Language:

english

File:

PDF, 876 KB

english, 2000

10

The realm of vitamin K dependent proteins: Shifting from coagulation toward calcification

Willems, Brecht A. G., Vermeer, Cees, Reutelingsperger, Chris P. M., Schurgers, Leon J.

Journal:

Molecular Nutrition & Food Research

Year:

2014

Language:

english

File:

PDF, 669 KB

english, 2014

11

The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children

van Summeren, Marieke J. H., Braam, Lavienja A. J. L. M., Lilien, Marc R., Schurgers, Leon J., Kuis, Wietse, Vermeer, Cees

Journal:

British Journal Of Nutrition

Year:

2009

Language:

english

File:

PDF, 239 KB

english, 2009

12

Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjects

Theuwissen, Elke, Cranenburg, Ellen C., Knapen, Marjo H., Magdeleyns, Elke J., Teunissen, Kirsten J., Schurgers, Leon J., Smit, Egbert, Vermeer, Cees

Journal:

British Journal Of Nutrition

Year:

2012

Language:

english

File:

PDF, 119 KB

english, 2012

13

Does statins promote vascular calcification in chronic kidney disease?

Chen, Zhimin, Qureshi, Abdul Rashid, Parini, Paolo, Hurt-Camejo, Eva, Ripsweden, Jonaz, Brismar, Torkel B., Barany, Peter, Jaminon, Armand M., Schurgers, Leon J., Heimbürger, Olof, Lindholm, Bengt, St

Journal:

European Journal of Clinical Investigation

Year:

2017

Language:

english

File:

PDF, 436 KB

english, 2017

14

Calcific aortic valve stenosis: hard disease in the heart

Peeters, Frederique E C M, Meex, Steven J R, Dweck, Marc R, Aikawa, Elena, Crijns, Harry J G M, Schurgers, Leon J, Kietselaer, Bas L J H

Journal:

European Heart Journal

Year:

2017

Language:

english

File:

PDF, 426 KB

english, 2017

15

Molecular Imaging of Cell Death in Tumors. Increasing Annexin A5 Size Reduces Contribution of Phosphatidylserine-Targeting Function to Tumor Uptake

Ungethüm, Lisette, Chatrou, Martijn, Kusters, Dennis, Schurgers, Leon, Reutelingsperger, Chris P., Hoffmann, Andreas-Claudius

Journal:

Year:

2014

Language:

english

File:

PDF, 3.71 MB

english, 2014

16

Bicuspid Aortic Valve Stenosis and the Effect of Vitamin K2 on Calcification Using 18F-Sodium Fluoride Positron Emission Tomography/Magnetic Resonance: The BASIK2 Rationale and Trial Design

Peeters, Frederique, van Mourik, Manouk, Meex, Steven, Bucerius, Jan, Schalla, Simon, Gerretsen, Suzanne, Mihl, Casper, Dweck, Marc, Schurgers, Leon, Wildberger, Joachim, Crijns, Harry, Kietselaer, Ba

Journal:

Year:

2018

Language:

english

File:

PDF, 1.05 MB

english, 2018

17

High-Dose Menaquinone-7 Supplementation Reduces Cardiovascular Calcification in a Murine Model of Extraosseous Calcification

Scheiber, Daniel, Veulemans, Verena, Horn, Patrick, Chatrou, Martijn, Potthoff, Sebastian, Kelm, Malte, Schurgers, Leon, Westenfeld, Ralf

Journal:

Year:

2015

Language:

english

File:

PDF, 909 KB

english, 2015

18

Reduced vitamin K status as a potentially modifiable risk factor of severe COVID-19

Dofferhoff, Anton S M, Piscaer, Ianthe, Schurgers, Leon J, Visser, Margot P J, van den Ouweland, Jody M W, de Jong, Pim A, Gosens, Reinoud, Hackeng, Tilman M, van Daal, Henny, Lux, Petra, Maassen, Cec

Journal:

Clinical Infectious Diseases

Year:

2020

File:

PDF, 929 KB

2020

19

The external quality assurance of phylloquinone (vitamin K1) analysis in human serum

David J. Card, Martin J. Shearer, Leon J. Schurgers, Dominic J. Harrington

Journal:

Biomedical Chromatography

Year:

2009

Language:

english

File:

PDF, 276 KB

english, 2009

20

Deficiencies of calcium-regulatory proteins in dialysis patients: A novel concept of cardiovascular calcification in uremia

Ketteler, Markus, Wanner, Christoph, Metzger, Thomas, Bongartz, Philipp, Westenfeld, Ralf, Gladziwa, Ulrich, Schurgers, Leon J., Vermeer, Cees, Jahnen-Dechent, Willi, Floege, Jurgen

Journal:

Kidney International

Year:

2003

Language:

english

File:

PDF, 83 KB

english, 2003

21

Molecular characterization of soluble factors from human menstrual effluent that induce epithelial to mesenchymal transitions in mesothelial cells

Ayşe Y. Demir, Patrick G. Groothuis, Gerard A. J. Dunselman, Leon Schurgers, Johannes L. H. Evers, Anton F. P. M. de Goeij

Journal:

Cell and Tissue Research

Year:

2005

Language:

english

File:

PDF, 992 KB

english, 2005

22

Circulating calcification inhibitors and vascular properties in children after renal transplantation

Marieke J. H. van Summeren, Jeroen M. Hameleers, Leon J. Schurgers, Arnold P. G. Hoeks, Cuno S. P. M. Uiterwaal, Thilo Krüger, Cees Vermeer, Wietse Kuis, Marc R. Lilien

Journal:

Pediatric Nephrology

Year:

2008

Language:

english

File:

PDF, 192 KB

english, 2008

23

Calcium scores and matrix Gla protein levels: association with vitamin K status

Roger J. M. W. Rennenberg, Peter W. De Leeuw, Alphons G. H. Kessels, Leon J. Schurgers, Cees Vermeer, Jos M. A. Van Engelshoven, Gerrit J. Kemerink, Abraham A. Kroon

Journal:

European Journal of Clinical Investigation

Year:

2010

Language:

english

File:

PDF, 91 KB

english, 2010

24

Mutations in the GGCX and ABCC6 Genes in a Family with Pseudoxanthoma Elasticum-Like Phenotypes

Li, Qiaoli, Grange, Dorothy K, Armstrong, Nicole L, Whelan, Alison J, Hurley, Maria Y, Rishavy, Mark A, Hallgren, Kevin W, Berkner, Kathleen L, Schurgers, Leon J, Jiang, Qiujie

Journal:

The Journal of Investigative Dermatology

Year:

2008

Language:

english

File:

PDF, 12.97 MB

english, 2008

25

Low serum vitamin K in PXE results in defective carboxylation of mineralization inhibitors similar to the GGCX mutations in the PXE-like syndrome

Vanakker, Olivier M, Martin, Ludovic, Schurgers, Leon J, Quaglino, Daniela, Costrop, Laura, Vermeer, Cees, Pasquali-Ronchetti, Ivonne, Coucke, Paul J, De Paepe, Anne

Journal:

Laboratory Investigation

Year:

2010

Language:

english

File:

PDF, 552 KB

english, 2010

26

Matrix Gla protein is involved in elastic fiber calcification in the dermis of pseudoxanthoma elasticum patients

Gheduzzi, Dealba, Boraldi, Federica, Annovi, Giulia, DeVincenzi, Chiara Paolinelli, Schurgers, Leon J, Vermeer, Cees, Quaglino, Daniela, Pasquali Ronchetti, Ivonne

Journal:

Laboratory Investigation

Year:

2007

Language:

english

File:

PDF, 693 KB

english, 2007

27

A fluorescent method to determine vitamin K-dependent gamma-glutamyl carboxylase activity

Nadine Kaesler, Thomas Schettgen, Vasantha P. Mutucumarana, Vincent Brandenburg, Willi Jahnen-Dechent, Leon J. Schurgers, Thilo Krüger

Journal:

Analytical Biochemistry

Year:

2012

Language:

english

File:

PDF, 852 KB

english, 2012

28

Rapidly Progressive Severe Vascular Calcification Sparing the Kidney Allograft Following Warfarin Initiation

Marta Hristova, Christine van Beek, Leon J. Schurgers, Beate Lanske, John Danziger

Journal:

American Journal of Kidney Diseases

Year:

2010

Language:

english

File:

PDF, 1.10 MB

english, 2010

29

Arterial calcifications

Roger. J. M. W. Rennenberg, Leon J. Schurgers, Abraham A. Kroon, Coen D. A. Stehouwer

Journal:

Journal of Cellular and Molecular Medicine

Year:

2010

Language:

english

File:

PDF, 524 KB

english, 2010

30

Matrix gla protein (MGP): an overexpressed and migration-promoting mesenchymal component in glioblastoma

Sonja Mertsch, Leon J Schurgers, Kathrin Weber, Werner Paulus, Volker Senner

Journal:

Year:

2009

Language:

english

File:

PDF, 3.44 MB

english, 2009

31

Microcalcifications in Early Intimal Lesions of Atherosclerotic Human Coronary Arteries

Ruben B. Roijers, Nicola Debernardi, Jack P.M. Cleutjens, Leon J. Schurgers, Peter H.A. Mutsaers, Ger J. van der Vusse

Journal:

The American Journal of Pathology

Year:

2011

Language:

english

File:

PDF, 2.23 MB

english, 2011

32

Pseudoxanthoma elasticum: Reduced γ-glutamyl carboxylation of matrix gla protein in a mouse model (Abcc6−/−)

Qiaoli Li, Qiujie Jiang, Leon J. Schurgers, Jouni Uitto

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 1.55 MB

english, 2007

33

Vascular calcification: The price to pay for anticoagulation therapy with vitamin K-antagonists

Martijn L.L. Chatrou, Kristien Winckers, Tilman M. Hackeng, Chris P. Reutelingsperger, Leon J. Schurgers

Journal:

Year:

2012

Language:

english

File:

PDF, 1.16 MB

english, 2012

34

Characteristics and performance of an immunosorbent assay for human matrix Gla-protein

Leon J. Schurgers, Kirsten J.F. Teunissen, Marjo H.J. Knapen, Piet Geusens, Desiree van der Heijde, Martijn Kwaijtaal, Rob van Diest, Markus Ketteler, Cees Vermeer

Journal:

Clinica Chimica Acta

Year:

2005

Language:

english

File:

PDF, 265 KB

english, 2005

35

PS198. Vitamin K2 Reduces Neointimal Hyperplasia and Calcification in a Uraemia Arteriovenous Fistula Rat Model

Maria Kokozidou, Stefan Langer, Michael Jacobs, Leon Schurgers, Tina Kessler, Jennifer Kranz, Thilo Krüger, Lieven Kennes, Thomas A. Koeppel

Journal:

Journal of Vascular Surgery

Year:

2011

Language:

english

File:

PDF, 81 KB

english, 2011

36

GGCX and ABCC6 gene mutations in a family with PXE-like phenotype

Qiaoli Li, Dorothy K. Grange, Nicole L. Armstrong, M. Yadira Hurley, Mark Rishavy, Kevin Hallgren, Kathleen L. Berkner, Leon J. Schurgers, Qiujie Jiang, Jouni Uitto

Journal:

Year:

2008

Language:

english

File:

PDF, 74 KB

english, 2008

37

Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification

Reidar Wallin, Leon Schurgers, Nadeem Wajih

Journal:

Thrombosis Research

Year:

2008

Language:

english

File:

PDF, 467 KB

english, 2008

38

Co-Existent Pseudoxanthoma Elasticum and Vitamin K-Dependent Coagulation Factor Deficiency: Compound Heterozygosity for Mutations in the GGCX Gene

Qiaoli Li, Leon J. Schurgers, Ann C.M. Smith, Maria Tsokos, Jouni Uitto, Edward W. Cowen

Journal:

The American Journal of Pathology

Year:

2009

Language:

english

File:

PDF, 677 KB

english, 2009

39

Matrix Gla Protein Accumulates at the Border of Regions of Calcification and Normal Tissue in the Media of the Arterial Vessel Wall

Henri M.H. Spronk, Berry A.M. Soute, Leon J. Schurgers, Jack P.M. Cleutjens, Henk H.W. Thijssen, Jo G.R. De Mey, Cees Vermeer

Journal:

Biochemical and Biophysical Research Communications

Year:

2001

Language:

english

File:

PDF, 218 KB

english, 2001

40

Incorporation of Disulfide Containing Protein Modules into Multivalent Antigenic Conjugates: Generation of Antibodies against the Thrombin-Sensitive Region of Murine Protein S

Van de Vijver, Pieter, Schmitt, Martin, Suylen, Dennis, Scheer, Liesbeth, Thomassen, M. Christella L. G. D., Schurgers, Leon J., Griffin, John H., Koenen, Rory R., Hackeng, Tilman M.

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 1.12 MB

english, 2012

41

Relationship between CT anthropometric measurements, adipokines and abdominal aortic calcification

Jonathan Golledge, Rumal Jayalath, Lisa Oliver, Adam Parr, Leon Schurgers, Paula Clancy

Journal:

Atherosclerosis

Year:

2008

Language:

english

File:

PDF, 291 KB

english, 2008

42

The association of uncarboxylated matrix Gla protein with mitral annular calcification differs by diabetes status: The Heart and Soul study

Benjamin D. Parker, Leon J. Schurgers, Cees Vermeer, Nelson B. Schiller, Mary A. Whooley, Joachim H. Ix

Journal:

Atherosclerosis

Year:

2010

Language:

english

File:

PDF, 204 KB

english, 2010

43

INCREASED CIRCULATING MATRIX GLA PROTEIN IN HEART FAILURE-ASSOCIATION WITH FUNCTIONAL, HEMODYNAMIC AND NEUROHORMONAL DISEASE SEVERITY

Thor Ueland, Christen P. Dahl, Lars Gullestad, Pal Aukrust, Sven Aakhus, Kaspar Broch, Cees Vermeer, Leon J. Schurgers

Journal:

Journal of the American College of Cardiology

Year:

2010

Language:

english

File:

PDF, 60 KB

english, 2010

44

Molecular Imaging to Identify the Vulnerable Plaque—From Basic Research to Clinical Practice

Dennis H. M. Kusters, Jan Tegtmeier, Leon J. Schurgers, Chris P. M. Reutelingsperger

Journal:

Molecular Imaging and Biology

Year:

2012

Language:

english

File:

PDF, 480 KB

english, 2012

45

Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women

Toshiro Sato, Leon J Schurgers, Kazuhiro Uenishi

Journal:

Nutrition Journal

Year:

2012

Language:

english

File:

PDF, 151 KB

english, 2012

46

Vitamin K: key vitamin in controlling vascular calcification in chronic kidney disease

Schurgers, Leon J

Journal:

Kidney International

Year:

2013

Language:

english

File:

PDF, 244 KB

english, 2013

47

Mutations in the ABCC6 Gene as a Cause of Generalized Arterial Calcification of Infancy: Genotypic Overlap with Pseudoxanthoma Elasticum

Li, Qiaoli, Brodsky, Jill L, Conlin, Laura K, Pawel, Bruce, Glatz, Andrew C, Gafni, Rachel I, Schurgers, Leon, Uitto, Jouni, Hakonarson, Hakon, Deardorff, Matthew A, Levine, Michael A

Journal:

The Journal of Investigative Dermatology

Year:

2014

Language:

english

File:

PDF, 1.58 MB

english, 2014

48

Warfarin Accelerates Ectopic Mineralization in Abcc6−/− Mice

Li, Qiaoli, Guo, Haitao, Chou, David W., Harrington, Dominic J., Schurgers, Leon J., Terry, Sharon F., Uitto, Jouni

Journal:

The American Journal of Pathology

Year:

2013

Language:

english

File:

PDF, 1.99 MB

english, 2013

49

Analysis of Calcifications in Patients with Coral Reef Aorta

Schlieper, Georg, Grotemeyer, Dirk, Aretz, Anke, Schurgers, Leon J., Krüger, Thilo, Rehbein, Hermann, Weirich, Thomas E., Westenfeld, Ralf, Brandenburg, Vincent M., Eitner, Frank

Journal:

Annals of Vascular Surgery

Year:

2010

Language:

english

File:

PDF, 1.58 MB

english, 2010

50

Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization

Schurgers, Leon J., Uitto, Jouni, Reutelingsperger, Chris P.

Journal:

Trends in Molecular Medicine

Year:

2013

Language:

english

File:

PDF, 2.01 MB

english, 2013